With pretty much any amp model I use I find that I need to cut the bass and gain more than I initially expect to. Also, drive block in front of the amp. I'd definitely start there rather than jumping into multi-band compression.
I generally drop the bass setting on the amp down to around 2 or 3.
Gain, depending on the amp, is usually from 2.5-4 (FAS Modern seems more gainy than equivalent amps such as the Recto. I usually have the gain on the low end of that range for it specifically)
Adjust presence to taste.
I occasionally turn on cut in addition to that.
Drive block (808 or 808 mod), the usual: drive off, level up around 8.5-10, tone 5+
Sometimes I'll add a peq block after the cab, blocking below anywhere from 80-130
And, quite possibly my biggest recommendation: fiddle with settings for 15 minutes, take a break for a bit, then come back to fiddling.