That will be subjective with a lot of people. I use a QSC power amp and Vox 2-12 cabs for amp models. Some use the Mission powered FRFR cabs, some use The Friedman FRFR cabs. Some will go with QSC k-12 PA powered PA or other powered PA cabs.To me most FRFR cabs are over priced when a separate power amp and flat full range speakers sounds just as good. Having separate things to hook up is a little more trouble, but with me if it ain't broke, don't fix it.
The best thing to do is select a budget that you want to spend. You do want to stay stereo, so you will need two sets. Stereo is a world of difference from mono. If you don't mind spending the money, it appears Friedman and Mission are the best Powered FRFR. I also have the QSC K-12 Cabs but only have one cab. If I were going with a powered PA speaker
Yamaha DZR12 2000W 12" Powered Speaker is the best for the money with a 2 in tweeter voice coil. That is not RMS power I don't think. I compared them with my QSC k-12 and The Yamaha's are better. You get what you pay for, but I do think the Mission and Friedman are overpriced. Many will disagree, but 2 of the Yamaha's above is the best for sound and power.
Many have the problem of playing at home on studio monitors then going out live and being disappointed with their sound. The Yamaha will get you closer to the studio monitor mix at home. I have Adam Reference Monitors and they are very flat, so to me a high end powered PA is the best if you are starting from scratch. The Axe FX has a global EQ to adjust the difference between your home reference Monitors and your live rigs. With good Reference monitors at home and the Yamaha rig very little will need to be changed. FRFR cabs for guitar seems a little boomy from my home mix.