Fixed That fer yaAny one have a good Bonamassa pre set
In all seriousness; the Marshall selection in the Axe is so awesome you could go a number of different ways and get amazing results for this type of tone.
I"m pretty sure there is a sample of his Marshall Silver Jubilee settings somewhere... use that and that amp model, you get that ZZ Top "Nasty Dogs & Funky Kings" kind of greenbacks blowing up tone...
JB uses two amps, mids from one, and bass and treble from the other. It gives him that distorted tone with the feeling of headroom. He still sounds like himself through a simple combo amp though. Just need enough gain to turn down the guitar volume, roll off the treble and it still sings.
Two amp blocks would get you there easy. But since the AX8 doesn’t do two I’d start with a jubilee. And some serious chops.