So I decided when I got home today to hook up the FX8 and Mesa Mark IV as it has been a while since I've played it just so I could be sure to give accurate information.
I had it backwards in my previous post about which channel defaults in the Mark IV. The default channel is the Lead channel not ths Rhythm 1 channel.
You will need to leave the selector knob set to FT.SW. If you set it to this with no switches connected it should default to the Lead channel. If you plug in your FX8 relay switch to the Rhythm 1 channel external switch you can jump between Lead and Rhythm 1. If you plug in your FX8 relay to the Rhythm 2 external switch you can jump between Lead and Rhythm 2. If you use a splitter and two of the FX8 relays you can plug them into Rhythm 1 and Rhythm 2 and be able to switch between all three channels. One thing of note is you have to set the FX8 the opposite of how you may set it for a different amp (i.e. the Mark IV works the opposite of my IIC+ so I have to reverse the FX8 on/off settings for the channel switching). I am not sure about the other external switches as I have not used them with the FX8 and the OP was asking about channel switching anyway.
So in short, yes the Mark IV has a default channel and this method of channel switching works as verified today on my Mark IV. As I mentioned in my original reply my Mark IV is an A model. If you have a B then elephant rhino, but I would assume it would function the same way. Getcha pull.