I've used Fractal almost 10 years, real amps/cabs/pedals for 20+. I still use FR cabs, guitar cabs AND tube amps to this day, depending on scenario.
Here's MY thoughts, in no particular order:
1). This stuff is FUN! Enjoy the journey.
2). The best (mic'd) guitar sound I can personally deliver INTO A MIXER CHANNEL comes from a Fractal amp model and cab block. Hands down, no contest. Maybe Bob Rock or Rick Rubin or... maybe some of you guys can do better recording with real amps, but I sure as hell can't! I can't crank amps loud at home anyway.
3). In the jam room or on a weekend pub stage with my bands I still prefer the sound and feel of a real guitar cab. I recently bought a CLR too, best FR box I've heard yet, but it still didn't change my mind. I do like open-back cabs, that might have a lot to do with it.
4). Flexibility off the charts win for the Fractal, it can morph into ANY amp or cab or effect chain you could possibly want. If you actually need that, then great, but if you really just end up emulating one sound of that one amp, then you might as well use the real amp. Fractal is overkill.
So for recording or LARGE gigs I'd go Fractal FRFR, for my live weekend band rig I'm back to amps/pedals.