I run my Axe in stereo for years with no additional components, not even a pedal.
Recently bought a tube head as I didn’t had a real amp for years (because of the Axe).
I must say that 4CM is a killer setup and I use it a lot.
I actually took it to another level of W/D/W, so the FX etc instead of going into the amp head return are going out the Matrix stereo setup (GT1000 + 2 x NL212), the sound is not less than a killer!!!
It’s actually the best sound I ever had, combining a real head with the Axe goodness + heaving a MMGT22 controlling this spaceship rig, man that’s is so powerful.
However, it’s for home use only, I will never drag for a gig a 2 2x12 + 4x12 + amp head + 6U rack and…. A full blown pedal board.
Yes, the midi thing took a little time + programming specific presets for 4CM but it’s worth every second, it is a very good sounding setup.