It sounds like there's some confusion here. Low latency mode is still monitoring through your computer. Is there some reason you're monitoring through your computer? It's more common to monitor direct. That way you don't have to deal with any latency issues.
In any case, if you're monitoring through your computer, your audio interface (in this case the AxeFX) will have relatively little effect on your latency. Your latency will be effected more by your computer cpu, which affects how low you can turn down your audio buffer size, which will reduce your latency.